Fatty Acid Synthase Expression Negatively Correlates with PTEN and Predicts Peritoneal Dissemination of Gastric Cancer
نویسندگان
چکیده
Gastric cancer is the one of most prevalent common malignant tumors and the common cause of cancer related death in East Asia. Gastric cancer is associated with a short time to recurrence and a short survival period after recurrence. In China, age-standardized 5-year relative survival for gastric cancer was only 27.4 % (Zeng et al., 2014). Although advances in diagnostic and treatment technologies have offered long-term survival results for early gastric cancer, but the prognosis for advanced GC still remains poor. Advanced gastric cancer patients prone to progress to peritoneal carcinomatosis and the prognosis for gastric carcinoma patients with peritoneal dissemination are poor. The biomarker and mechanism causing peritoneal dissemination of gastric cancer cells is still poorly understood. Fatty acid synthase (FASN) is thought to be a key biosynthetic enzymes in lipogenesis, is regulated by hormones, growth factors and diet. And recent data indicate that it is expressed in several tumor cells. FASN is expressed at low levels in most normal tissues. By contrast,
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